The U.S. Environmental Protection Agency (EPA) has approved the residue tolerances for Isocycloseram, a novel insecticidal active ingredient (IRAC Group 30), to include brassica crops, including cabbage, broccoli and kale.

The California Department of Pesticide Regulation (DPR) registration is still pending. California is a major producer of brassicas and other specialty vegetables, and growers have been in dire need for pest control solutions to support with resistance and significant economic and pest damage pressures over the past few years.

A significant challenge for brassica growers is the diamondback moth (DBM) and developed resistance to many existing pest control tools, making control difficult and costly. Isocycloseram is a new broad-spectrum insecticide in the isoxazolines chemical class, which have an insecticidal mode of action based on allosteric modulation of the gamma aminobutyric acid (GABA) receptor.

The announcement includes tolerances for crops including basil, beans, cane berries, brassicas, celery, citrus, leafy greens, melons, onions, stone fruits and other commodities.

Read full announcement here: https://www.federalregister.gov/documents/2025/11/20/2025-20460/isocycloseram-pesticide-tolerances